副研究员
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徐文忠 副研究员 硕士生导师

办公地点：图资楼111

联系电话：(86)-010-62836654

电子邮件：xuwzh@ibcas.ac.cn

课题组：芍药科多样性与种质创新团队 


个人简历：

1974年2月生于湖南城步县，1996年在湖南农业大学茶学系获学士学位，1999年在中国农业大学生物学院植物生理生化系获硕士学位，2003年在中国科学院植物研究所获博士学位。2013年10月至2014年10月美国佛罗里达国际大学Dr. Barry P. Rosen教授实验室访问学者。2003年至今：中国科学院植物研究所研究实习员、助理研究员、副研究员。

主要研究内容：

1、资源植物基因组编辑育种

以芍药科芍药属（牡丹和芍药）、小浆果（树莓、蓝莓、蓝靛果、黑加仑）、木本油料作物（山桐子）、景天属（伴矿景天、东南景天）等野生资源和特色资源植物为研究材料，建立其组培快繁技术方法，构建其遗传转化技术平台，针对控制其重要的农艺性状、品质特性、环境适应性等相关的关键基因，进行基因组编辑育种，利用现代分子技术手段培育出高观赏价值、高营养价值、高抗逆性等新品种。 

2、植物吸收、转运重金属及信号应答的分子机理

以重金属（如镉、砷等）超积累植物和模式植物（水稻、拟南芥）为材料，利用分子生物学和生物信息学的研究手段和方法，挖掘和克隆植物转运重金属相关的重要基因，阐明重金属在植物个体及器官、组织、细胞中转移运输的分子机理，应用基因技术调控重金属在植物中的转运和积累；同时研究植物激素（如生长素、赤霉素、乙烯等）和myo-肌醇多磷酸信号在重金属逆境胁迫及其对植物生长发育影响中的作用和功能，揭示重金属对植物的毒害机理和植物细胞的应答机制及信号传导。

研究论文（注*为通讯作者）：

  1. Haixia Zhao, Liangsheng Wang, Fang-Jie Zhao, Longhua Wu, Anna Liu, Wenzhong Xu*. SpHMA1 is a chloroplast cadmium exporter protecting photochemical reactions in the Cd hyperaccumulator Sedum plumbizincicola. Plant, Cell & Environment, 2019, 42:1112-1124.
  2. Dandan Yin, Shanshan Li, Qingyan Shu, Zhaoyu Gu, Qian Wu, Chengyong Feng, Wenzhong Xu*, Liangsheng Wang*. Identification of microRNAs and long non-coding RNAs involved in fatty acid biosynthesis in tree peony seeds. Gene, 2018, 5; 666:72-82.
  3. Dandan Yin, Wenzhong Xu, Qingyan Shu, Shanshan Li*, Qian Wu, Chengyong Feng, Zhaoyu Gu, Liangsheng Wang*. Fatty acid desaturase 3 (PsFAD3) from Paeonia suffruticosa reveals high α-linolenic acid accumulation. Plant Science, 2018, 274: 212-222.
  4. 尹丹丹、李珊珊、吴倩、冯成庸、李冰、王倩玉、王亮生*、徐文忠*. 我国6种主要木本油料作物的研究进展. 植物学报，2018, 53(1): 110-125.
  5. Qian Wu, Pengcheng Li, Huijin Zhang, Chengyong Feng, Shanshan Li*, Dandan Yin, Jie Tian, Wenzhong Xu, Liangsheng Wang*. Relationship between the flavonoid composition and flower colour variation in Victoria. Plant Biol (Stuttg), 2018, 20(4): 674-681.
  6. Huan Liu, Haixia Zhao, Longhua Wu, Anna Liu, Fang-Jie Zhao, Wenzhong Xu*. Heavy metal ATPase 3 (HMA3) confers cadmium hypertolerance on the cadmium/zinc hyperaccumulator Sedum plumbizincicola. New Phytologist, 2017, 215(2): 687-698.
  7. Huan Liu, Haixia Zhao, Longhua Wu*, Wenzhong Xu*. A genetic transformation method for cadmium hyperaccumulator Sedum plumbizincicola and non-hyperaccumulating ecotype of Sedum alfredii. Frontiers in Plant Science, 2017, 8:1047.
  8. Bo Wang†, Hong Du†, Zhennan Zhang, Wenzhong Xu*, Xin Deng*. BhbZIP60 from Resurrection plant Boea hygrometrica is an mRNA splicing-activated endoplasmic reticulum stress regulator involved in drought tolerance. Frontiers in Plant Science, 2017, 8:245.
  9. Dongmei Li, Zhenpeng Guo*, Cuimei Liu, Jincheng Li, Wenzhong Xu, Yi Chen*. Quantification of near-attomole gibberellins in floral organs dissected from a single Arabidopsis thaliana flower. Plant Journal, 2017, 91(3):547-557.
  10. Hongmei Xi, Hua Xu, Wenxiu Xu, Zhenyan He, Wenzhong Xu*, Mi Ma*. A SAL1 loss-of-function Arabidopsis mutant exhibits enhanced cadmium tolerance in association with alleviation of endoplasmic reticulum stress. Plant & Cell Physiology, 2016, 57(6): 1210–1219.
  11. Yangyang Sun†, Wenzhong Xu†(co-first author), Li Wu, Ruozhong Wang, Zhenyan He, Mi Ma*. An Arabidopsis mutant of inositol pentakisphosphate 2-kinase AtIPK1 displays reduced arsenate tolerance. Plant, Cell & Environment, 2016, 39: 416-426.
  12. Zhuoya Zhao†, Zenan Xing†, Min Zhou, Yi Chen, Chenzhong Li, Ruozhong Wang, Wenzhong Xu*, Mi Ma. Functional analysis of synthetic DELLA domain peptides and bioactive gibberellin assay using surface plasmon resonance technology. Talanta, 2015, 144: 502–509.
  13. Hui Dong, Wenzhong Xu, Jitesh K. Pillai, Charles Packianathan, Barry P. Rosen*. High-throughput screening-compatible assays of As(III) S-adenosylmethionine methyltransferase activity. Analytical Biochemistry, 2015, 480:67-73.
  14. Wenzhong Xu†, Wentao Dai†, Huili Yan, Sheng Li, Hongling Shen, Yanshan Chen, Hua Xu, Yangyang Sun, Zhenyan He, Mi Ma*. Arabidopsis NIP3;1 plays an important role in arsenic uptake and root-to-shoot translocation under arsenite stress conditions. Molecular Plant, 2015, 8(5):722-33.
  15. Zhuoya Zhao, Yanshan Chen, Wenzhong Xu*, Mi Ma. Surface plasmon resonance detection of transgenic Cry1Ac cotton (Gossypium spp.). Journal of Agricultural and Food Chemistry, 2013, 61(12):2964-2969.
  16. Yanshan Chen†, Wenzhong Xu† (co-first author), Hongling Shen, Huili Yan, Wenxiu Xu, Zhenyan He, Mi Ma*. Engineering arsenic tolerance and hyperaccumulation in plants for phytoremediation by a PvACR3 transgenic approach. Environmental Science & Technology,2013, 47 (16): 9355–9362
  17. Hua Xu†, Wenzhong Xu†(co-first author), Hongmei Xi, Wenwen Ma, Zhenyan He, Mi Ma*. The ER luminal binding protein (BiP) alleviates Cd2%2b-induced programmed cell death through endoplasmic reticulum stress–cell death signaling pathway in tobacco cells. Journal of Plant Physiology, 2013, 170 (16): 1434–1441.
  18. 吴俐、王若仲、徐文忠*. 拟南芥中myo-肌醇-多磷酸合成与代谢及其信号. 植物学报, 2013. 48 (1): 94–106.
  19. Jiangbo Guo, Wenzhong Xu, Mi Ma*. The assembly of metals chelation by thiols and vacuolar compartmentalization conferred increased tolerance to and accumulation of cadmium and arsenic in transgenic Arabidopsis thaliana. Journal of Hazardous Materials, 2012. 199-200: 309-313.
  20. 刘安娜、腾瑶、徐文忠*、麻密. 一个编码含VQ 模序蛋白的基因AtARVQ1参与拟南芥对砷酸盐的响应调控. 科学通报, 2011.56(23):1891-1898.
  21. Yao Teng, Wenzhong Xu*, Mi Ma. cGMP is required for seed germination in Arabidopsis thaliana. Journal of Plant Physiology, 2010, 167(11):885-9.
  22. Beibei Li†, Wenzhong Xu†(co-first author), Yunyuan Xu, Yuanyuan Zhang, Tai Wang, Yue Bai, Chenggui Han, Aimin Zhang, Zhihong Xu and Kang Chong*. Integrative study on proteomics, molecular physiology, and genetics reveals an accumulation of cyclophilin-like protein, TaCYP20-2, leading to an increase of Rht protein and dwarf in a novel GA-insensitive mutant (gaid) in Wheat. Journal of Proteome Research, 2010, 9(8):4242-53.
  23. Wenwen Ma†, Wenzhong Xu†(co-first author), Hua Xu, Yanshan Chen, Zhenyan He, Mi Ma*. Nitric oxide modulates cadmium influx during cadmium-induced programmed cell death in tobacco BY-2 cells. Planta, 2010, 232(2):325-35.
  24. Xuexi Yang, Hui Chen, Xiaojing Dai, Wenzhong Xu, Zhenyan He and Mi Ma*. Evidence of vacuolar compartmentalization of arsenic in the hyperaccumulator Pteris vittata. Chinese Science Bulletin 2009, 54(22): 4229-4233.
  25. Jiangbo Guo, Xiaojing Dai, Wenzhong Xu, Mi Ma*. Overexpressing GSH1 and AsPCS1 simultaneously increases the tolerance and accumulation of cadmium and arsenic in Arabidopsis thaliana. Chemosphere 2008, 72: 1020-1026.
  26. Yongqiang Zheng, Xiaojing Dai, Lei Wang, Wenzhong Xu, Zhenyan He, Mi Ma*. Arsenate reduces copper phytotoxicity in gametophytes of Pteris vittata. Journal of Plant Physiology 2008, 165: 1906-1916.
  27. Yongqiang Zheng, Wenzhong Xu, Zhenyan He, Mi Ma*.  Plant regeneration of the arsenic hyperaccumulator Pteris vittata L. from spores and identification of its tolerance and accumulation of arsenic and copper. Acta Physiologiae Plantarum 2008, 30: 249-255.
  28. Xuexi Yang, Hui Chen, Wenzhong Xu, Zhenyan He, Mi Ma*.  Hyperaccumulation of arsenic by callus, sporophytes and gametophytes of Pteris vittata cultured in vitro. Plant Cell Reports 2007, 26: 1889-1897
  29. Jiangchuan Li, Jiangbo Guo, Wenzhong Xu, Mi Ma*. RNAi-mediated silencing of phytochelatin synthase gene reduce cadmium accumulation in rice seeds. Journal of Integrative Plant Biology 2007, 49: 1032-1037.
  30. Haiyan Zhang, Wenzhong Xu, Wentao Dai, Zhenyan He, Mi Ma*. Functional characterization of cadmium-responsive garlic gene AsMT2b: a new member of metallothionein family. Chinese Science Bulletin 2006, 51: 409-416.
  31. Jiangchuan Li, Jiangbo Guo, Wenzhong Xu, Haiyan Zhang, Mi Ma*. Enhanced cadmium accumulation in transgenic tobacco expressing the phytochelatin synthase gene of Cynodon dactylon. Journal of Integrative Plant Biology 2006, 48: 928-937.
  32. 詹宝、徐文忠、麻密*. 砷超富集植物蜈蚣草原生质体的分离及其抗砷性分析. 植物学通报 2006, 23(4): 363-367.
  33. Haiyan Zhang, Wenzhong Xu, Jiangbo Guo, Zhenyan He, Mi Ma*. Coordinated responses of phytochelatins and metallothioneins to heavy metals in garlic seedlings. Plant Science 2005, 169: 1059-1065.
  34. 徐文忠、雍伟东、徐云远、梁铁兵、白薇、种康*、谭克辉、许智宏、朱至清. 利用反义基因技术分析春化相关基因VER17在小麦花发育和开花中的功能. 植物生理与分子生物学学报 2005, 31: 71-77.
  35. 孙振元*，徐文忠，赵梁军，刘淑兰. 高pH值和铁素对毛白杜鹃和迎红杜鹃根系Fe3%2b还原酶活性的影响. 核农学报 2005, 19(6): 456-460.
  36. Wenzhong Xu, Xin Wang, Qi Feng, Lei Zhang, Yaoguang Liu, Bin Han, Kang Chong*, Zhihong Xu, Kehui Tan. The VER2 promoter contains repeated sequences and requires vernalization for its activity in winter wheat (Triticum aestivum L.). Chinese Science Bulletin 2004, 49: 355-362.
  37. Xin Wang, Wenzhong Xu, Yunyuan Xu, Kang Chong*, Zhihong Xu, Guixian Xia. Wheat RAN1, a nuclear small G protein, is involved in regulation of cell division in yeast. Plant Science 2004, 167: 1183-1190.
  38. Weidong Yong, Yunyuan Xu, Wenzhong Xu, Ning Li, Jinsong Wu, Tiebing Liang, Kang Chong*, Zhihong Xu, Kehui Tan. Functional analysis of the VER2 gene, related to vernalization during floral development in winter wheat. Planta 2003, 217: 261-270.
  39. 孙振元*、徐文忠、刘淑兰、赵梁军. 毛白杜鹃耐碱突变体的离体筛选与鉴定. 中南林学院学报 2003, 23(5):53-55.
  40. Shiqian Jia, Weidong Yong, Wenzhong Xu, Yunyuan Xu, Jingsong Wu, Kang Chong*, Kehui Tan, Zhihong Xu. Existence of homologous sequences corresponding to cDNA of the ver gene in diverse higher plant species. Cell Research 2001, 11(4):265-271.

国家发明专利：

1.  徐文忠，麻密，赵卓亚. 一种定性定量检测植物激素活性赤霉素的方法及其专用芯片. 专利号：     ZL201310381641.1.

2. 徐文忠，麻密，陈焱山. PvARRP1蛋白及其编码基因在砷转运解毒和积累中的应用. 申请号：201210394041.4, 公开号：CN102899348A.

3.  麻密，徐文忠，赵卓亚. 一种检测植物中目标蛋白的方法及其专用SPR生物传感器. 专利号：ZL201110081230.1.

4. 麻密，赵卓亚，徐文忠. 一种检测植物中目标基因的方法及其专用SPR生物传感器.申请号： 201110100899.0, 公开号：CN102181555A 

5. 徐文忠，麻密，戴晓静，孙洋洋，何振艳. 一种与砷响应相关的调控片段及其应用. 专利号: ZL201010128600.8. 

6.  何振艳，麻密，徐文忠，陈宏林. 一种植物砷抗性相关的蛋白及其编码基因与应用. 专利号: ZL 201010116397.2

7. 孙振元，徐文忠，赵梁军，巨关升，韩 蕾，杨学军. 一种迎红杜鹃组培快繁和移栽方法. 专利号: ZL 200510090496.7

8. 麻密，何振艳，徐文忠，杨学习. 一种蜈蚣草ABC转运蛋白及其编码基因与应用. 专利号: ZL200410080857.5.

9. 麻密，李江川，郭江波，徐文忠，何振艳. 一种培育低重金属积累植物的方法. 专利号:  ZL200410096858.9.

10. 种康，徐文忠，王昕，韩斌，徐云远，谭克辉，许智宏. 小麦VER2基因启动子. 专利号: ZL200410000680.3.

11. 种康，雍伟东，徐云远，徐文忠，梁铁兵，鲍时来，许智宏，谭克辉.  一种与春化作用相关的可控制小麦花期的基因. 专利号: ZL00136714.5.

著作专著：

徐文忠、张海燕、刘俊祥. 重金属对药用植物品质形成的影响. 主编：卢善发，《药用植物品质生物学》，科学出版社，2019: p73-96.

谭克辉，徐文忠，种康. 高等植物个体发育的调控. 主编：叶和春，《探索绿色世界》，山东画报出版社，2001：p219-246.