邓馨 研究员 博士生导师
办公室：新实验楼 E117
电子邮箱： deng@ibcas.ac.cn
电话：010-62836261；010-62836892
传真：010-62836261
课题组：植物干旱逆境适应及调控技术研究组
个人简历：
1993年获黑龙江八一农垦大学学士学位，1996年获沈阳农业大学硕士学位，1999年获中国科学院植物研究所理学博士学位。1999至2003年在德国马普植物育种所进行博士后研究，2005年在德国波恩大学作访问学者，2009至2010年在美国加州大学河滨分校作访问学者。2003年到植物所工作。2006年入选北京市科技新星计划。在PLOS Genetics、Plant and Cell Physiology、Plant Molecular Biology等期刊发表论文65篇；申请国家发明专利18项，其中11项获得授权。已培养硕士和博士34名，包括2名国际留学生；正在指导博士后1名、硕博研究生7名。Current Plant Biology副主编。
主要研究工作：
关注植物耐旱耐干耐贮问题，利用牛耳草等复苏植物和玉米等作物进行了系列研究，发掘了有效提高植物抗旱性的基因资源，创制了部分抗旱玉米材料。1） 脱水干燥不但是植物早期登陆的重要限制因素，植物适应严重干旱环境的关键机制，还是种子成熟的必经过程，对种子活力和粮食耐贮性重要。复苏植物在长期的进化过程中形成了独特的适应机制，可以忍耐>95%水分的丧失，并可在重新供水时复苏。我们对亚洲特有复苏植物旋蒴苣苔（Boea hygrometrica）展开了系统的组学研究和分子生物细胞学研究，报道了其独特的耐干转录与转录后调控和代谢组重编程、DNA甲基化修饰参与耐干记忆的表观遗传调控，并通过国际合作比较了亚欧分布的苦苣苔科复苏植物耐干机制的差异。2）利用玉米等作物的群体材料研究抗旱耐盐的关键分子元件，并探索其应用价值。
近五年主持和参加的科研项目：
[1] “干旱胁迫下复苏植物旋蒴苣苔调控自噬阻抑细胞死亡的分子机制”，国家自然科学基金面上项目（2023.01-2026.12），项目负责人。
[2] “利用复苏植物抗旱重编程信号激活模式提高作物抗逆性”，科技部重点研发计划国际合作项目（2021.07-2024.06），项目负责人。
[3] “基于比较基因组/EST-mapping的苦苣苔科植物耐干性获得研究”，中国科学院国际人才交流计划（2021.10.1-2023.9.30），项目负责人。
[4] “复苏植物牛耳草干旱胁迫记忆基因的表观调控”，国家自然科学基金面上项目（2018.01-2021.12），项目负责人。
[5] “甜高粱与饲用玉米复杂性状解析与新品种定向分子选育”， 中国科学院战略性先导科技专项子课题（2020.11-2025.10），骨干。
研究论文
2022
Mladenov P*, Zasheva D, Planchon S, Leclercq C, Falconet D, Moyet L, Brugière S, Moyankova D, Tchorbadjieva M, Ferro M, Rolland N, Renaut J, Djilianov D, Deng X* (2022). Proteomics Evidence of a Systemic Response to Desiccation in the Resurrection Plant Haberlea rhodopensis. International Journal of Molecular Sciences 23: 8520.
Nergui K, Jin S, Zhao L, Liu X, Xu T, Wei J, Chen X, Yang Y, Li H, Liu Y, Wang Y, Liu J, Zhao T, Li Y, Tang L, Sun R, Wang X, Liu Y, Deng X* (2022). Comparative analysis of physiological, agronomic and transcriptional responses to drought stress in wheat local varieties from Mongolia and Northern China. Plant Physiology and Biochemistry 170: 23-35.
Tang L, Wang Y, Wang W, Deng X, Wang X* (2022) Genome-wide identification of CrRLK1L gene family and desiccation-induced expression profiles in Boea hygrometrica, Current Plant Biology, 31, 100256.
2021
Sun R. Z, Liu J, Wang YY, & Deng X*. DNA methylation-mediated modulation of rapid desiccation tolerance acquisition and dehydration stress memory in the resurrection plant Boea hygrometrica. PLOS Genetics 2021. 17(4): e1009549. https://doi.org/10.1371/journal.pgen.1009549
2020
Sun R*, Zuo E, Qi J, Liu Y，Lin C, Deng X* (2020). A role of age-dependent DNA methylation reprogramming in regulating the regeneration capacity of Boea hygrometrica leaves. Funct Integr Genomics. 20(1):133-149. https://doi.org/10.1007/s10142-019-00701-3
2019
Lin C, Xu T, Xing S, Zhao L, Sun R, Liu Y, Moore J, Deng X* (2019). Weighted correlation network analysis (WGCNA) reveals the hub role of protein ubiquitination in the acquisition of desiccation tolerance in Boea hygrometrica. Plant Cell Physiol 60(12):2707-2719.
Liu J, Moyankova D, Djilianov D*, Deng X* (2019). Common and specific mechanisms of desiccation tolerance in two Gesneriaceae resurrection plants. Multiomics evidences. Frontiers in Plant Science. 10. 10.3389/fpls.2019.01067.
Wang X, Song K, Li Y, Tang L, Deng X* (2019). Single-molecule imaging and computational microscopy approaches clarify the mechanism of the dimerization and membrane interactions of green fluorescent protein. International Journal of Molecular Sciences 20: 1410.
2018
Sun RZ*, Lin CT, Zhang XF, Duan LX, Qi XQ, Gong YH, Deng X* (2018). Acclimation-induced metabolic reprogramming contributes to rapid desiccation tolerance acquisition in Boea hygrometrica. Environ. Exp. Bot., 148: 70-84.
Liu J§, Moyankova D§, Lin CT§, Mladenov P§, Sun RZ, Djilianov D*, Deng X* (2018). Transcriptome reprogramming during severe dehydration contributes to physiological and metabolic changes in the resurrection plant Haberlea rhodopensis. BMC Plant Biol., 18: 351. （§为共同第一作者）
2017
Wang B, Du H, Zhang Z, Xu W*, Deng X* (2017). BhbZIP60 from resurrection plant Boea hygrometrica is an mRNA splicing-activated endoplasmic reticulum stress regulator involved in drought tolerance. Frontiers in Plant Science, 8: 245.
2016
Lin S, Zhao Y, Zhu Y, Gosney M, Deng X, Wang X, Lin J* (2016). An effective and inducible system of TAL effector-mediated transcriptional repression in Arabidopsis. Molecular Plant 9(11): 1546-1549.
刘杰, Lin Chih-Ta, 邓馨* (2016). 复苏植物耐脱水机制研究进展. 生物技术通报 32(10): 42-51.
2015
Zhu Y, Wang B, Phillips J, Zhang ZN, Du H, Xu T, Huang LC, Zhang XF, Xu GH, Li WL, Wang Z, Wang L, Liu YX, Deng X* (2015). Global transcriptome analysis reveals acclimation-primed processes involved in the acquisition of desiccation tolerance in Boea hygrometrica. Plant and Cell Physiology 56:1429-1441.
陈世璇，张振南，王波，朱燕*，龚月桦*，孙冬梅，邓馨 (2015) 复苏植物旋蒴苣苔J结构域蛋白编码基因BhDNAJC2的克隆、表达与功能。植物学报50(2): 180-190
Xiao L, Yang G, Zhang L, Yang X, Zhao S, Ji Z, Zhou Q, Hu M, Wang Y, Chen M, Xu Y, Jin H, Xiao X, Hu G, Bao F, Hu Y, Wan P, Li L, Deng X, Kuang T, Xiang C, Zhu JK*, Oliver MJ*, He Y* (2015). The resurrection genome of Boea hygrometrica: A blueprint for survival of dehydration. Proc Natl Acad Sci USA. 112(18): 5833-5837
2014
Li W, Xu F, Chen S, Zhang Z, Zhao Y, Jin Y, Li M, Zhu Y, Liu Y, Yang Y, Deng X* (2014). A comparative study on Ca content and distribution in two Gesneriaceae species reveals distinctive mechanisms to cope with high rhizospheric soluble calcium. Frontiers in Plant Science 5: 647
王策，杨艳歌，吕维涛*，周春菊*，孙冬梅，邓馨 (2014). 玉米A亚族bZIP转录因子基因ZmbZIP81的克隆、表达与功能分析。作物学报40: 1549-1556.
张晓飞，段礼新，龚月桦*，邓馨* (2014). 基于GC-MS的复苏植物牛耳草代谢物提取方法的比较。生物工程学报30(2): 294-304.
Zhao Y, Xu T, Shen CY, Xu GH, Chen SX, Song LZ, Li MJ, Wang LL, Zhu Y, Lv WT, Gong ZZ, Liu CM, Deng X* (2014). Identification of a retroelement from the resurrection plant Boea hygrometrica that confers osmotic and alkaline tolerance in Arabidopsis thaliana. PLoS ONE 9(5): e98098.
Zhao Y, Shen CY, Xu T, Chen SX, Li WL, Deng X* (2014). A 30-kb genomic DNA fragment of resurrection plant Boea hygrometrica enhances Arabidopsis osmotic and alkaline tolerance. Journal of Food, Agriculture and Environment 12(1): 210-215
Li WL, Duan HK, Chen FY, Wang Z, Huang XQ, Deng X, Liu YX* (2014). Identification of quantitative trait loci controlling high calcium response in Arabidopsis thaliana. PLoS ONE 9(11): e112511.
2013
Yang YG, Lv WT, Li MJ, Wang B, Sun DM*, Deng X* (2013). 
Maize membrane-bound transcription factor Zmbzip17 is a key regulator in the crosstalk of ER quality control and ABA signaling. Plant and Cell Physiology, 54(12): 2020–2033
Mitra J, Xu G, Wang B, Li M and Deng X* (2013). Understanding desiccation tolerance using the resurrection plant Boea hygrometrica as a model system. Frontiers in Plant Science, 4: 446
杨艳歌，吕维涛，孙冬梅*，凌毅*，邓馨* (2013). 玉米D亚族bZIP转录因子基因的数据库挖掘、分析、克隆与表达. 作物学报39 (12): 2115-2122
Zhang ZN, Wang B, Sun DM* & Deng X* (2013). Molecular cloning and differential expression of sHSP gene family members from the resurrection plant Boea hygrometrica in response to abiotic stresses. Biologia 68(4).
Wang Z, Cao H, Sun YZ, Li XY, Chen FY, Carles A., Li Y, Ding M, Zhang C, Deng X, Soppe WJJ, Liu YX* (2013). Arabidopsis paired amphipathic helix proteins SNL1and SNL2 redundantly regulate primary seed dormancy via abscisic acid-ethylene antagonism mediated by histone deacetylation. Plant Cell, 25:149-166.
2012
Duan HK, Zhu Y, Li WL, Qi DD, Liu YX, Deng X* (2012). Comparative study on the expression of genes involved in carotenoid and ABA biosynthetic pathway in response to salt stress in tomato. Journal of Integrative Agriculture 11(7): 1093-1102.
Zheng J, Chen FY, Wang Z, Cao H, Li XY, Deng X, Soppe Wim JJ, Li Y and Liu YX* (2012). A novel role for histone methyltransferase KYP？SUVH4 in the control of Arabidopsis primary seed dormancy. New Phytologist 193: 605–616.
2011
王智，刘永秀，魏建华，邓馨* (2011). 复苏植物牛耳草中棉子糖系列寡糖及棉子糖合酶基因的研究. 植物学报，47(1):44-54
张兰军，姬飞腾，王丽丽，亓岽东，朱燕，邓馨* (2011). 复苏植物旋蒴苣苔C2结构域小蛋白BhC2DP1以依赖于Ca2+的方式参与植物对ABA的反应. 植物学报，47(1):11-27
Duan HK, Zhu Y, Li WL, Qi DD, Liu YX, Deng X * (2011). Comparative study on the expression of genes involved in carotenoid and ABA biosynthetic pathway in response to salt stress in tomato. Agricultural Sciences in China, 11(7): 1093-1102
2010及以前
Wang Z, Zhu Y, Wang LL, Liu X, Liu YX, Phillips J, Deng X * (2009). A WRKY transcription factor participates in dehydration tolerance in Boea hygrometrica by binding to the W-box elements of the galactinol synthase (BhGolS1) promoter. Planta 230: 1155-1166
Zhu Y, Wang Z, Jing YJ, Wang LL, Liu X, Liu YX, Deng X * (2009). Ectopic over-expression of BhHsf1, a heat shock factor from the resurrection plant Boea hygrometrica, leads to increased thermotolerance and retarded growth in transgenic Arabidopsis and tobacco. Plant Molecular Biology 71: 451-67
Wang LL, Shang HH, Liu YX, Zheng MZ, Wu RH, Phillips J, Bartels D, Deng X * (2009). A role for a cell wall localized glycine-rich protein in dehydration and rehydration of the resurrection plant Boea hygrometrica. Plant Biology 11: 837-848
姬飞腾，李楠，邓馨* (2009). 喀斯特地区植物钙含量特征与高钙适应方式分析. 植物生态学报33：926-935
Wu RH, Wang LL, Wang Z, Shang HH, Liu X, Zhu Y, Qi DD, Deng X * (2009). Cloning and expression analysis of a dirigent protein gene from the resurrection plant Boea hygrometrica. Progress in Natural Science 19: 347-352
Liu X, Wang Z, Wang LL, Wu RH, Phillips J, Deng X * (2008). LEA 4 group genes from the resurrection plant Boea hygrometrica confer dehydration tolerance in transgenic tobacco. Plant Science 176: 90–98
刘霞，邓馨* (2008). 复苏植物牛耳草BhLEA2基因启动子的分离和基因表达模式研究. 自然科学进展19：39-44
Jiang GQ, Wang Z, Shang HH, Yang WL, Hu ZA, Phillips J, Deng X* (2007). Proteome analysis of leaves from the resurrection plant Boea hygrometrica in response to dehydration and rehydration. Planta 225 (6):1405-1420
Deng X, Phillips J, Brautigam A. Engstr?m P, Johannesson H, Ouwerkerk P, Ruberti I, Salinas J, Vera P, Iannacone R, Meijer A, Bartels D* (2006). A homeodomain leucine zipper gene from Craterostigma plantagineum regulates abscisic acid responsive gene expression and physiological responses. Plant Molecular Biology 61(3): 469-489
Deng X, Hu ZA*, Wang HX, Wen XG, Kuang TY (2003). Changes in Photosynthetic Functions of a Resurrection Angiosperm Boea hygrometrica (Bunge) R.Br. (Gesneriaceae) during desiccation and rehydration. Plant Science 165(4): 851-861
Deng X, Phillips J, Meijer A, Salamini F, Bartels D* (2002). Characterization of five novel dehydration-responsive homeodomain leucine zipper genes from the resurrection plant Craterostigma plantagineum. Plant Molecular Biology 49 (6): 601-610.
授权专利：
蛋白BhDnaJ6及其编码基因与应用，邓馨等，国家发明专利，专利号201710969733.X 授权公告日2022.05.10
蛋白ZmbZIPa3及其编码基因在调控植物生长发育与耐逆性中的应用，邓馨等，国家发明专利，专利号201810721970.9授权公告日2022.3.1
一种可提高植物耐旱盐碱性的蛋白BhDNAJC2及其编码基因与应用，邓馨等，国家发明专利，专利号201410176146.1 申请日2014.4.29, 授权日2018.10.02
蛋白BhHSP70-1及其编码基因与应用 邓馨等，国家发明专利，专利号201210581636.0，授权日期2016.1.20
转录因子ZmbZIP17及编码基因与其在响应逆境中的应用，邓馨等，国家发明专利，专利号201310065802.6 ，授权日期 2016.5.30
一种与植物耐旱相关的蛋白及其编码基因与应用，邓馨等，国家发明专利，专利号201310149496.4 ，授权日期2016.6.20
植物耐旱耐碱相关的DNA片段及其应用 邓馨等，国家发明专利，专利号ZL 201210135602.9，授权日期 2015.1.14
与植物抗逆相关的热激因子蛋白及其编码基因与应用,邓馨等，国家发明专利，专利号200910078056.8，授权日期 2013.3.20
一种与植物抗旱相关的蛋白及其编码基因与应用, 邓馨等，国家发明专利，专利号200810223541.5，授权日期 2012年3月14日
旋蒴苣苔的肌醇半乳糖苷合成酶基因及其编码蛋白与应用 邓馨等， 国家发明专利，专利号200510112540.X，授权日期 2008年1月23日
一个旋蒴苣苔的抗旱、耐盐相关基因及其编码蛋白与应用，邓馨等，国家发明专利，专利号200510127881.4，授权日期2007年10月24日
获奖及荣誉：
2006年入选北京市科技新星计划。
2021年获得潍坊市科学技术进步奖（排名第2）。